Dec 17, 2019 the hepatoprotective impact of the extract of sp might be as a result of its free radical scavenging and antioxidant activities. A lot of herbal plants and polyherbal formulations are used for the treatment of liver diseases. Vanillin, a phenolic aldehyde has been reported to possess antioxidant and free radical scavenging ability kamat et al. Apr 23, 2008 the present study was carried out to evaluate ficus glomerata extracts for antioxidant and hepatoprotective properties. The aim of the study is to investigate the hepatoprotective activity of melia. A number of studies have shown that the plant extracts having antioxidant activity protect against ccl4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity shahjahan et al. Aqueous extract of asparagus racemosus root aear was evaluated for its hepatoprotective activities in rats. The results obtained showed that these extracts possess significant hepatoprotective activity.
Hepatoprotective activity of some medicinal plants in sudan hindawi. Silymarin as a standard drug for comparing the activity. Hepatoprotective activity of the extract of homalium. Investigations on hepatoprotective activity of leaf extracts. Hepatoprotective activity of aqueous and ethanolic bixa orellana l. Hepatoprotective activities of ethanolic and aqueous extracts of a. The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Hepatoprotective activity of water extracts from chaga. The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of pulicaria. Hepatoprotective activity of the ethanolic extract of ficus. Original article, clinical report by journal of evolution of medical and dental sciences.
Hepatoprotective activity of fruit extracts of phyllanthus. The present study was carried out to screen and evaluate the hepatoprotective activity of leaf extracts of aegle marmelos l. Hepatoprotective activity of an herbal composition, map, a. Different medicinal herbs and plants extracts have potent hepatoprotective activity in various animal models. Molecules free fulltext antioxidant and hepatoprotective. Hepatoprotective and antioxidant effect of stem barks. Hepatoprotective effect of leaf extracts from citrus hystrix. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Hepatoprotective activity of capparis decidua aqueous and. Jun 19, 2018 the potential hepatoprotective activities of two lannea species were explored in vivo. In the in vivo studies, the ccl4 treated control rats showed a significant alteration in the levels of antioxidant and hepatoprotective.
The methanol extracts of plant materials of some plants like casuarina equisetifolia, cajanus cajan, glycosmis pentaphylla, bixa orellana, argemone mexicana, physalis minima, caesalpinia bonduc, belonging to the different family were studied for. The strong antioxidant activity of this extract explains the significant. The present investigation is aimed to evaluate the hepatoprotective effects of citrus hystrix and citrus maxima red and white variety methanolic leaf extracts on paracetamol induced toxicity. So the plant may be useful in the management of free radical mediated diseases. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim. Hepatoprotective activity of 50% ethanolic leaf extracts of parkinsonia aculeata was evaluated against carbon tetrachloride ccl 4induced hepatic damage in rats. It was found that the antioxidant activity of the ethyl acetate extract of v. Pdf medicinal plants possessed hepatoprotective activity. Hepatoprotective effect of aqueous extracts of some medicinal. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world.
This may indicate that the plant extracts contain compounds, which can remove toxic metabolites following tbh induced toxicity. Hepatoprotective activity of water extracts from chaga medicinal mushroom, inonotus obliquus higher basidiomycetes against tertbutyl hydroperoxideinduced oxidative liver injury in primary cultured rat hepatocytes. The hepatoprotective activity of methanol extract of aerial parts of canna indica l. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models. There is area for further study to characterize the active principle responsible for the hepatoprotective activity of the plant. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats. Pp hydroalcoholic leaf extract, a plant rich in antioxidant, on hepatic ischemiareperfusion ir injury. Hepatoprotective activity of capparis decidua aqueous and methanolic stems extracts against carbon tetrachloride induced liver histological damage in rats. Hepatoprotective activity of ethanolic extract of salix subserrata. The plant phenolic compounds such as flavonoids and isoflavons have an important role in the treatment of many diseases and some of them induce a potent antioxidant and hepatoprotective effect. Keeping this view in the mind, bark extracts of terminalia catappa was selected for to evaluate the hepatoprotective activity. L leaves extracts against simvastatin induced hepatotoxicity. Pdf hepatoprotective activity of methanol extract of. Hepatoprotective activity of melia azedarach leaf extract against simvastatin induced hepatotoxicity a.
In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. The extract at doses of 100, 200 and 300 mg kg1 body weight were administered orally once daily. Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. Antioxidant activity of spilanthes acmella extracts. Antimicrobial activity of some plant extracts having. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4.
Historically, botanicals have been reported to possess good antioxidative activities as demonstrated by their free radical scavenging property rendering their usage in liver protection. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. The hepatoprotective and antioxidant activity of aqueous and methanolic extracts of pseudocedrela kotschyi stem bark was confirmed by biochemical, antioxidant and histopathological studies. Hepatoprotective effect of leaf extracts of parkinsonia. The present study was designed to assess the hepatoprotective activity and cytotoxicity of methanolic and water extracts of f. Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by induction of. Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs. In vitro antioxidant and in vivo hepatoprotective activity of. Hepatoprotective activity of the ethanolic extract of ficus caricalinn. Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. Antioxidant and hepatoprotective activity of methanolic and. This hepatotoxic activity can be measured using sgot, sgpt and mda.
Hepatoprotective and antioxidant activity of standardized. In this study, we describe the potential use of map, a standardized blend comprising three extracts from myristica fragrans, astragalus membranaceus, and. Hepatoprotective activity of melia azedarach leaf extract. The hepatoprotective activity is probably due to the presence of flavonoids, phenolic compounds, polyphenols etc in all few herbal plants. The highest antioxidant activity was found in ethyl acetate and nbutanol followed by dichloromethane, hexane, and aqueous extracts. Hepatoprotective activity of fruit extracts of phyllanthus acidus linn. In india, numerous medicinal plants are used for the treatment of liver disorders. Hepatoprotective and antioxidant activity of methanol extract. The invitro antioxidant activity was estimated for different extracts on superoxide, hydroxyl and 1,1 diphenyl2picrylhydrazyl free radicals and the hepatoprotective activity of the. Its hepatoprotective activity is attributed to its antioxidant properties. Ficus carica, hepatoprotective activity, carbontetra chloride, silymarin. It should be noted that the hepatoprotective effects of wc extract is probably because of its antioxidant activity as a free radical scavenger.
A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. Hepatoprotective activity of some indigenous plants. Pdf a search for hepatoprotective activity of fruit. The free radical mediated process has been implicated in the pathogenesis of different diseases. Hepatoprotective activity of cinnamon ethanolic extract. Hepatoprotective activity was measured based on biochemical parameters. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. Aqueous and alcoholic extracts of terminalia catappa were taken. The extracts exhibited significant antioxidant property as evident by the trolox values and effective scavenging of dpph. The basic plant material of melia azedarach linn used for. This work screened the hepatoprotective and antioxidant activity of ethanol ers, and aqueous ars, extracts of leaves of raphanus sativus in carbon tetrachloride ccl4, model in rats.
Oxidative stress analytical chemistry free radical plant extract vital role. Hepatoprotective activity of methanolic extract of bauhinia. Pdf hepatoprotective activity of some plants extract against. Health, general albinism carbon tetrachloride usage liver liver diseases medical research medicine, experimental. The goal of the present study was to examine the antioxidant and hepatoprotective activity of some medicinal. Leaf extracts were given in the dose of 200 mgkg body weight for 7 days and toxicity was induced by paracetamol 2 gkg on day 5. Tanninrich extracts from lannea stuhlmannii and lannea. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. The hepatoprotective activity of the plant may be attributed to the phenolic compounds, flavonoids, and saponins 6164. There are many plants and traditional formulations available to treat the liver diseases 5, 6. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. Pdf hepatoprotective activity of methanolic extract of. Pdf hepatoprotective activity of some plants extract. Potent free radical scavenging capacity of pongamia pinnata can be attributed to different flavones present in the extracts.
Because phenolic and flavonoid compounds are recognized as the bases of the antioxidant activity of plant extracts, we determined the phenolic and flavonoid content of vcfe. This present investigation was aimed to assess the hepatoprotective activity of aqueous and ethanol extract of pongamia pinnata leaves against acetaminopheninduced liver damage in albino rats. Hepatoprotective activity of flavonoids is due to their ability to scavenge free radicals. The extracts were subjected to antioxidant tests total reducing power and total phenolic content, and preliminary phytochemical. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim abstract the aim of the study is to investigate the hepatoprotective activity of melia azedarach leaves extracts against simvastatin induced hepatotoxicity. Antimicrobial activity of some plant extracts having hepatoprotective effects ammara hassan, salma rahman, farah deeba and shahid mahmud applied chemistry research centre, pcsir labs. Hepatoprotective activity of methanol extract of melastoma. Evaluation of the cytotoxic activity of extracts from medicinal plants used for the treatment of malaria in kagera and lindi regions, tanzania. The liver damaging effect of ccl4 is explained by its ability to produce trichloromethyl free radicals and reactive oxygen species ros after being. The results showed that wc extract reduced oxidative stress by increasing tsh content as well as enhancing gpx activity. Hepatoprotective and antioxidant activity of watercress. The finding of the present study implied that the ethanolic extract of sp may be taken into account as a valuable substitute to adjust hepatotoxicity induced by apap. Pdf evaluation of the cytotoxic activity of extracts. Hepatoprotective activity of some medicinal plants in sudan.959 288 523 1063 344 16 883 874 1612 648 422 777 1059 1414 292 1095 1265 896 1196 816 406 1155 348 1060 891 1208 1270